Allergy & Clinical Immunology

Identification of neoepitopes is crucial for the efficacy of neoantigen vaccines. In this episode, experts discuss methods for selecting unique tumor mutations.

Immuno-oncologists at UCSD and La Jolla Institute discuss approaches to cancer vaccines that target tumor-specific neoantigens unique to each patient's cancer, resulting in custom-made cancer therapy.

Oncologists discuss research into altering the microbiome through fecal transplant or changes in diet to improve tumor response to immune checkpoint inhibitors.

Experts discuss differences seen in the microbiomes of anti-PD1 responders and nonresponders and the potential mechanisms for a microbial effect on response.