This transcript has been edited for clarity.
Michelle L. O'Donoghue, MD, MPH: Hi. This is Dr Michelle O'Donoghue, reporting for Medscape. We're here in Philadelphia at the American Heart Association Scientific Sessions where one of the big stories has been ORBITA-2. The primary results were presented. Joining me here today are Rasha Al-Lamee and Chris Rajkumar, both from Imperial College in the UK. Before we talk about ORBITA-2, perhaps you could set the stage, Rasha; where were we at after ORBITA-1? What were the takeaways there?
ORBITA-1 Recap
Rasha Al-Lamee, MBBS, MA, PhD: Thank you very much, Michelle, for having us here. After ORBITA-1, you will remember well the fallout that came. Obviously, it was the first placebo-controlled trial of stable coronary artery disease and percutaneous coronary intervention (PCI), comparing PCI with a placebo procedure in patients who had guideline-directed medical therapy.
Importantly, the patients were on an average of three antianginal agents prior to being randomized. And what we found was that the benefit of angioplasty above placebo was far smaller than we expected, and in fact, not statistically significant on the primary endpoint of exercise time. Broadly, there was very little to talk to in terms of symptom relief; one in five more patients were free of angina.
COMMENTARY
PCI, the Antianginal 'Pill': ORBITA-2 in Detail
Michelle L. O'Donoghue, MD, MPH; Rasha Al-Lamee, MBBS, MA, PhD; Christopher A. Rajkumar, MBBS, PhD
DisclosuresNovember 15, 2023
This transcript has been edited for clarity.
Michelle L. O'Donoghue, MD, MPH: Hi. This is Dr Michelle O'Donoghue, reporting for Medscape. We're here in Philadelphia at the American Heart Association Scientific Sessions where one of the big stories has been ORBITA-2. The primary results were presented. Joining me here today are Rasha Al-Lamee and Chris Rajkumar, both from Imperial College in the UK. Before we talk about ORBITA-2, perhaps you could set the stage, Rasha; where were we at after ORBITA-1? What were the takeaways there?
ORBITA-1 Recap
Rasha Al-Lamee, MBBS, MA, PhD: Thank you very much, Michelle, for having us here. After ORBITA-1, you will remember well the fallout that came. Obviously, it was the first placebo-controlled trial of stable coronary artery disease and percutaneous coronary intervention (PCI), comparing PCI with a placebo procedure in patients who had guideline-directed medical therapy.
Importantly, the patients were on an average of three antianginal agents prior to being randomized. And what we found was that the benefit of angioplasty above placebo was far smaller than we expected, and in fact, not statistically significant on the primary endpoint of exercise time. Broadly, there was very little to talk to in terms of symptom relief; one in five more patients were free of angina.
Cite this: PCI, the Antianginal 'Pill': ORBITA-2 in Detail - Medscape - Nov 15, 2023.
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Authors and Disclosures
Authors and Disclosures
Authors
Michelle L. O'Donoghue, MD, MPH
Senior Investigator, TIMI Study Group; Associate Professor of Medicine, Harvard Medical School; Associate Physician, Brigham and Women's Hospital, Boston, Massachusetts
Disclosure: Michelle L. O'Donoghue, MD, MPH, has disclosed the following relevant financial relationships:
Serve(d) as a consultant for: Janssen; Novartis; CVS Minute Clinic
Received research grant from: Merck & Co., Inc.; GlaxoSmithKline; Eisai Inc.; AstraZeneca Pharmaceuticals LP; Janssen Pharmaceuticals; Medicines Company; Amgen
The opinions expressed in this article are solely my own and do not necessarily reflect the views and opinions of Brigham and Women's Hospital.
Rasha Al-Lamee, MBBS, MA, PhD
Interventional Cardiology Consultant, Imperial College London, London, United Kingdom
Disclosure: Rasha Al-Lamee, MBBS, MA, PhD, has disclosed the following relevant financial relationships:
Serve(d) as a director, officer, partner, employee, advisor, consultant, or trustee for: Janssen
Serve(d) as a speaker or a member of a speakers bureau for: Philips; Abbott; Medtronic; Servier; Menarini
Christopher A. Rajkumar, MBBS, PhD
Imperial College Healthcare NHS Trust, Division of Cardiology Cardiothoracic and Thoracic Surgery, London, United Kingdom
Disclosure: Christopher A. Rajkumar, MBBS, PhD, has disclosed the following relevant financial relationships:
Received 'speakers fees from: Menarini
Received consultant fees from: Philips