Mpox-Associated Hospitalization Among JYNNEOS Vaccinated Persons
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Reduced Odds of Mpox-Associated Hospitalization Among Persons Who Received JYNNEOS Vaccine

California, May 2022-May 2023

Samuel Schildhauer, MPH; Kayla Saadeh, MPH; Josh Vance, MPH, MEd; Joshua Quint, PhD; Tarek Salih, MD; Timothy Lo, MPH; Awa Keinde, MPH; Edwin Chojolan, MPH; Esther Gotlieb, MPH; Marisa Ramos, PhD; Eric Chapman; Philip Peters, MD; Jessica Watson, MD; Kelly A. Johnson, MD; Eric C. Tang, MD; Kathleen Jacobson, MD; Robert Snyder, PhD

Disclosures

Morbidity and Mortality Weekly Report. 2023;72(36):992-996. 

In This Article

Abstract and Introduction

Abstract

The effectiveness of 1 dose of JYNNEOS vaccine (modified vaccinia Ankara vaccine, Bavarian Nordic) against hospitalization for mpox (caused by Monkeypox virus), has been demonstrated; however, the impact of 2 doses on hospitalization risk, especially among persons infected with HIV, who are at higher risk for severe disease, is an important factor in evaluating vaccine effectiveness against mpox disease severity and Monkeypox virusinfection. Surveillance data collected by the California Department of Public Health were used to evaluate whether receipt of 2 doses of JYNNEOS vaccine reduced the odds of hospitalization among persons with mpox. The odds of hospitalization among persons with mpox who had received 1 or 2 JYNNEOS doses were 0.27 (95% CI = 0.08–0.65) and 0.20 (95% CI = 0.01–0.90), respectively, compared with unvaccinated mpox patients. In mpox patients with HIV infection, the odds of hospitalization among those who had received 1 JYNNEOS vaccine dose was 0.28 (95% CI = 0.05–0.91) times that of those who were unvaccinated. No mpox-associated hospitalizations were identified among persons infected with HIV who had received 2 JYNNEOS vaccine doses. To optimize durable immunity, all eligible persons at risk for mpox, especially those infected with HIV, should complete the 2-dose JYNNEOS series.

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